寒性膿瘍に対するSM注入の意義

概要

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The biochemical changes were observed as the result of repeated streptomycin-infusion into the cold abscess.In one case of thoracic caries which was infused with 0.3-0.5gm. of SM at intervals of about a week, the pus diluted and tubercle bacilli in the pus decreased markedly in the quantitative cultures, and bacilli were not found by the Ziehl-Neelsen's stain.In one case of lumbar caries which was infused with 1gm. SM at intervals of more about 2 weeks, the pus did not seriously change and tubercle bacilli did not decrease.The human tubercle bacilli (H 37 RV) grew most markedly at range of pH 6.2-6.9 in liquid media (Youman's media), and SM effected much more at the range of pH 7.0 to pH 7.8 of media.The average range of pH of the pus in the 12 cases of cold abscess was about pH 7.5 so that the activity of SM in the cold abscess seems not to be inhibited by the pH of pus.The concentration of SM in serum exhibited maximal potencies after 3-6 hours of the infusion of SM (1.0gm.), but after 48-72 hours few of it was found, and the concentration of SM in the pus was 4.1-19.6γ/c. c. after a week.
西日本整形・災害外科学会の論文