Effects of pulsing electric magnetic field on callus formation of rats.

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Pulsing electric magnetic field (PEMF) can produce inductive current in the vital body without surgical invasion, and this micro-current has some biological effects. Rats with fractured or osteotomied femoral bones were bred in PEMF cage. Control rats were bred in the same structural cage, but without PEMF. Some from both groups of rats were sacrificed each week, and macroscopic, microscopic and radiographic analyses were performed. All through the experimental period, the control group could not achieve stabilization at fractured or osteotomied site. On the contrary, PEMF group were well stabilized by surrounding new soft tissue within a week. This soft tissue consisted of fibroblasts and collagen fiber. From 14 days to 20 days, callus formation and bone regeneration were accelerated. From radiographic analysis, tiny callus could be seen at 2nd week and perfect repair could be observed within 4th week. Histologically newly formed fibrous tissue within a week and hypervascularity in the callus were characteristic to PEMF group. From this analysis, PEMF is considered to be effective for callus formation. PEMF does not accelerate direct calcification, but it accelerates early fibroblast proliferation. These fibroblasts can stabilize the fractured components and can accelerate early callus production retrospectively. Hypervascularity of the callus under PEMF plays an important role from the viewpoint of metabolism and mineral transport. Action site of PEMF is considered to be present between hematoma-phase and fibrous tissue-phase of bone-repair mechanism.
西日本整形・災害外科学会の論文

Effects of pulsing electric magnetic field on callus formation of rats.

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