Osteonecrosis of the femoral head in spontaneously hypertensive rats. Histochemical study of the cartilage in the femoral heads.:Histochemical study of the cartilage in the femoral heads

概要

論文の詳細を見る
To investigate the cause of osteonecrosis in the femoral head of spontaneously hypertensive rats (SHRs), the articular and growth cartilage in the femoral head was observed microscopically in 50 SHRs at the age of 5-9 weeks after birth. For histochemical examination, thin coronal sections of the femoral heads were stained with hematoxylin-eosin, toluidine blue, Alcian blue and safraninO.Osteonecrosis of the femoral head was found after 7 weeks of age. In the period of 5-7 weeks after birth, abnormal findings of the cartilage, such as subsidence of the articular cartilage, distortion and nodular proliferation of chondrocytes in the growth plate, appeared in the outer part of the femoral head where toluidine blue stain disclosed the decreased stainability. So, it suggests that abnormalities of the cartilage in the femoral head may take part in the occurrence of osteonecrosis of the femoral head in SHRs.
西日本整形・災害外科学会の論文