An Experimental Study into Effects of Anti-neoplastic Agents on Peripheral Nerve Recovery after Neurorrhaphy in Rats.

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We analysed the effect of adriamycin and cisplation, which are the most common anti-neoplastic agents for treatment of malingnant bone and soft tissue tumors, on peripheral nerve regeneration.The left sciatic nerve of Wistar rats was elected for the site of neurorrhaphy. Three groups of rats were prepared as follows, Group 1: Adriamycin of 5mg/kg weekly was administered through the lateral illiac artery after neurorrhaphy.Group 2: Cisplatin 5mg/kg was administered in the same manner.Group 3: Saline was injected in the same manner as a control. Each group consisted of 30 rats, and they were functionally assessed using the sciatic functional index. After 6 and 8 weeks they were sacrificed and each specimen was electrophysiologically and histologically evaluated.The results showed significant differences among the three groups, and any adverse effect of anti-neoplastic agents on nerve regeneration was proved.
西日本整形・災害外科学会の論文