The Effect of Vitamin K2 on Bone Mass in Ovariectomized Rats.

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The effect of vitamin K2 on bone mass of osteoporotic middle-aged female rats induced by ovariectomy was studied. OVX or Sham operations were performed at day 0. Vitamin K2 (Note to Author Please confirm which dose of vit K2 was given) was orally administered for 7 or 14 weeks and the rat was then sacrificed. After resecting the proximal tibias, X-ray pictures were taken and the bone area of each proximal tibial metaphysis was measured by computer.In experiment 1, in which vitamin K2 was given during the whole experimental period of 7 or 14 weeks, vitamin K2 did not inhibit the decrease in bone mass induced by ovariectomy.In experiment 2, in which no drug was administered for the first seven weeks, followed by vitamin K2 administration for the second 7 week period, vitamin K2 did not inhibit the decrease in bone mass.In conclusion, vitamin K2 did not influence the bone mass of the osteoporotic rats induced by ovariectomy.