Pharmacological studies on the embryonic heart of Oryzias laptipes (Medaka, Japanese Killfish):I. Action of hyaluronidase
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概要
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To study the influence of hyaluronidase on the permeability of eggs, the time until onset of the effects of the dyes on the heart-rate were measured after exposure to the Ringer's solutions containing basic, acid dyes or toxic protein. At 22°C, after 3-24 hours treatment by 2000 U/cc of hyaluronidase, the stable state of permeability can be maintained for 24 hours; irrespective from molecular weight and electric change, that is, drug can reach the heart as fast as that of larvae just hatched out. But 48 hours after hyaluronidase treatment, such state of permeability begins to decrease and after 72 hours, recovers to a certain level, a little higher than the state existing before the hyaluronidase treatment. This fact would show the recovery of vitelline membrane, not cholion.
- 社団法人 日本薬理学会の論文