Nicotine distribution in dog and rabbit

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Using the BrCN-Aniline method of estimation for nicotine reported previously (I. Yamamoto<I>et al</I>., 1954), plasma levels and tissue distribution of nicotine after subcutaneous injection of 5 mg/kg nicotine were investigated in dog and rabbit. 1) The highest plasma concentration in dog was found at 15 minutes after and its value was 5.7 per ml.. In rabbit its value was 4 per ml. at 30 minutes after and in the 5 hours plasma sample nicotine could not be proved. 2) After the administration of the same dose per weight the nicotine plasma level was lower in rabbit than dog. 3) The plasma erythrocyte ratio of nicotine distribution was 10 to 7. 4) The tissue distribution of nicotine in dog at one hour, was higher in kidney, pancreas and brain than any other tissue, in rabbit the results were almost the same except brain and at 6 hours after, nicotine could not be proved in any tissue.
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