On the influence of alcohol habit upon the narcotic action of barbiturates

概要

論文の詳細を見る
1) There is a cross-tolerance between alcohol and other central nervous system depressants, such as barbital and amytal; that is, a decrease was demonstrated in the rapidity of onset and duration of sleep produced by intravenous injection of barbital sodium, and also a decrease in the duration of amytal sleep when the drug was injected intravenously, in alcohol-tolerant animals [rabbits and albino rats (Wistar strain)]. 2) The content of these barbiturates in the blood and brain in alcohol-tolerant animals was lower than in the controls, but contrariwise, the content in the tissues other than brain [liver, muscle, kidney (especially after barbital) and lung (after amytal)] was found to be higher. 3) These experiments indicate that at least the reduced barbiturate narcosis demonstrated in alcohol-tolerant animals can be explained as a result of such changes in the distribution of barbiturates in the tissues.
社団法人日本薬理学会の論文