Pharmacological studies on embryonal stage.:On the influences of potassium iodide (KI) isonicotinic acid hydrazide (INAH) and para-amino-salicylic acid (PAS) on the chick embryo

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A slight inhibition in the development of chick embryo was noted with the injection of KI solution into developing hens' eggs, especially with the injection of highly concentrated solution. No malformation of embryo was recorded, and the eggs hatched perfectly with the exceptions in the cases with 20 mg and 30 mg of KI. The excretion of I into the allantoic fluid was found poor. The highest rate of excretion was 37.5% recorded in the case received the injection of 500γ of KI on the 15th day. In the cases with the injection of 10 mg of KI, the contents of I in the brain, heart and liver were found increased by the above order compared with those of the untreated control cases, and the weight of each of the above organs was also found increased. When developing hens' eggs were injected with 5mg of KI combined with 1.5mg of INAH or with 10mg of PAS-Na salt, the development of the chick embryo and the excretions of I, INAH and PAS into the allantoic fluid were inferior compared with those in the cases of their single administrations. As to the histological findings of the liver, regressive degenerations such as vacuolar degeneration, fatty degeneration and necrosis of the hepatic cells were recognized in the cases treated with KI exceeding 1 mg.
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