Effects of cardiac glycosides on the activity of cholinesterase
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概要
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The effects of such cardiac substances as digitalis and other glycosides on the activity of cholinesterase were scrutinizied. An infusion of digitalis leaves, a solution of digitoxin, that of digitoxigenin, digitalin, digitalein, <I>g</I>- and <I>k</I>-strophanthin, all inhibited the activity of cholineesterase on acetylcholine acting on the <I>M. rectus abdominis</I> of frogs. Those inhibitory effects of the drugs did not run parallel with the cardiac action and especially was not in accordance with their action to the pulse rate. Therefore it may be justified that the action of digitalis to retard a pulse rate will result not from its inhibitory action against cholinesterase but rather from the direct stimulation to the vagus-endings in the heart.
- 社団法人 日本薬理学会の論文