The influence of digitalis preparations upon the stomach-movement and E.K.G. of the pigeon
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概要
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Intravenous administration of digitalis-preparations (Digitoxin, Digitoxigenin, Digoxin, Strophanthin, Cedilanid and Digicorin-fraction) produced the so called. "Vomiting curve" of the stomach-movement of pigeons. After a definite time it recovered to its normal condition. There is no parallel relation among the vomiting-dose, dose of slowing of heart rate and L.D. (U.S.P.). When the vomiting curve and the slowing of heart rate recovered to normal, Digitoxin effect was the slowest, Digitoxigenin effect was most quickened and Cedilanid and Digicorin-fraction remained moderate. When Digitoxin was injected, the T wave of the E.K.G. showed the lowest value. In the case of Digitoxigenin, the depression of the T wave was still indicated after recovering from the slowing of heart rate. There was no depression on the T wave even when Digicorin-fraction and Cedilanid caused the slowing of heart rate. It can be assumed that the mechanism of vomiting and that of heart rate's slowing are not the same.
- 社団法人 日本薬理学会の論文