The influence of autonomic drugs upon the pain reflex inhibitory action of morphine
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概要
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Observing the response to a radiant heat, or, to a pressure applied to the tails of mice, and also observing electro-physiological phenomena in cats as a target, an investigation was made regarding the influence of autonomic drugs upon the morphine analgesia. By the radiant heat method, adrenaline, ephedrine, methylpropamine and pilocarpine potentiated the morphine action, while ACh, mecholyl and prostigmine showed no such action. The above mentioned effects of adrenergic drugs were abolished by dibenamine, but not by priscol. A similar effect was also observed by the pressure method. When adrenaline or ephedrine was also combined, even a subthreshold dose (4 mg/kg) of morphine diminished the polysynaptic reflex disharge in the intact cats, although this effect was not observed in the spinal cats or in the thalamic cat.
- 社団法人 日本薬理学会の論文