A newer method of circulating Perfusion of dog's head in situ, with its special references to factors concerned

概要

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A method has been devised for the perfusion of a dog's head connected to its body only by vago-sympathetic trunk and spinal cord. In order to separate completely the vascular system of the head from the body, it was shown to be necessary to transect all the skin and muscles around the neck at the level of occipito-atlantal joint and to occlude <I>A. spinalis anterior</I> and <I>Sinus columunae vertebralis</I> in vertebral canal. The completeness of the blockade of the blood circulation between head and body was checked by the injection of Evan's blue or adrenaline in either side of the circulation. The time course of survival and reactivity to drugs of the brain was also investigated. From the result obtained in 30 experiments it has been convinced that this method is one of the most excellent methods to observe the direct action of drugs upon brain centres.
社団法人日本薬理学会の論文