Pharmacology of heart of Entosphenus japonicus
スポンサーリンク
概要
- 論文の詳細を見る
The author investigated the effects of various autonomic nervous or cardiac drugs on the isolated heart of <I>Entosphenus japonicus</I>, a kind of eel, being taxonomically classified in the lowest of vertebrates. Atropine and adrenaline produced scarcely a cardiac action. Pilocarpine increased the heart frequency and augmented the ventricular contraction, with a simultaneous elevation of cardiac tonus, while, at high concentrations, it produced a systolic standstill. No antagonism was observed between atropine and pilocarpine. Both physostigmine and prostigmine produced the same cardiac action as pilocarpine did. Acetylcholine increased the heart frequency more significantly than the above drugs did and produced a diastolic standstill. Synthetic muscaririe had the almost same action as acetylcholine. Nicotine caused the ventricular fibrillation for a few minutes immediately after application. Extracts of digitalis leaves augmented the ventricular contraction and increased the heart frequency a little. Digitoxin greatly increased the heart frequency. Digitamin, one of digitalis preparations for injection, promoted the heart beat a little. <I>g</I>-Strophanthin produced the significant increase of the heart frequency and augmented the ventricular contraction. The ventricular tonus was also increased. No change was produced, on the heart frequency with vitacamphor. This drug augmented the ventricular contraction and regulated arrhythmia completely. The heart of <I>Entosphenus japonicus</I> differed in various point of responses to drugs from those of other vertebrates, and this should allow to assume a mechanism of autonomic or heart regulation for it, different from that of other animals.
- 社団法人 日本薬理学会の論文