Pharmacological studies on the phosphorus metabolism of the brain with radioactive isotope P32

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Radioactive phosphate (P32) was used to study influence of urethane on the P metabolism of rat's brain. The amounts of inorganic P in blood plasma and total, acid-soluble and residual P in the brain of rat under urethane anesthesia were determined, and the uptake of P32 by these fractions was measured at 3rd, 5th and 24th hrs after the intraperitoneal injection of the tracer by Geiger counter (Nuclear Model 166). The results were compared with controls (without urethane). (1) Inorgonic P in the plasma was increased under urethane anesthesia. (2) In anesthetized rats the specific activity (SA) of acid-soluble P increased at 3rd hrs, and that of residual P decreased at 5th and 24th hrs. (3) The SA of total P and acid-soluble organic P to that of inorganic P were not influenced significantly by urethane.
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