<I>Studies on the experimental leucopenia induced by Nitromin</I>
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概要
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A leucopenia is usually induced in a maximal extent after a single subcutaneous dosis of 25.0 mg/kg of Nitromin (methyl-bis-β-chloroethylamine-N-oxide HCl) in male rats weighing 150-250 g in body weight which would return to normal in 7-10 days. The rate of recovery to normal begins to be delayed at the third injection of repeated dose if applied every tenth day. The therapeutic effect of some compounds for the experimental leucopenia was studied where those compounds had been given 15 minutes prior to Nitromin injection and the shift of leucocyte : count was observed every twelfth hour thereafter. Among those compounds L-cystein HCl in a dosis of 500 mg/kg and Platonin, a photo-sensitive agent, in 50γ/kg were found well to prevent the leucopenia induced after Nitromin in 25.0 mg/kg.
- 社団法人 日本薬理学会の論文