Toxicological and pharmacological studies on coelomic fluid and body constituents of round-worms:(2). Their action against the circulatory system and some smooth muscle organs
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Subsequent to the experiments reported in the first issue in this series, the author studied the action of the coelomic and somatic fluids on excised hearts of frogs, the excised vessels of hind legs of toads, , the ear vessels of rabbits, the blood pressure and respiration in rabbits, and excised intestine and uteri of rabbits. The results obtained were as follows : Against the excised hearts of frogs, their reaction was directed against the cardiac muscles, depressantly in high concentration and stimulantly in low concentration. Against the peripheral blood vessels, they caused constriction in high concentration and dilatation in low concentration to the auricular vessels of rabbits, but to the excised vessels of hind legs of toads, the action was generally constrictive regardless of the concentration. Against blood pressure, coelomic fluid acted to heighten it at first and then depressantly, but the body extract always tends to depress it. This action anent the blood pressure is influenced neither by the central nor the vagal nerves. Respiration generally becomes shallow and slow, but in some cases, its frequency is enhanced. In respect of the movement of smooth muscle organs, I found that the coelomic fluid causes a passing depression of the autonomic movement of the excised intestine of rabbits, but the body extract containing fat tended to stimulate such movement. Such effects are seemingly caused by the direct attack on the muscles themselves by the fluids. Against the isolated uterus of rabbits, both the preparations acted stimulatingly to their autonomic movement. In looking over the observed actions of the round-worm poison, I found that not only the protein containing, but also the fat containing constituents in the body-extracts of the nematoda play a part in the occurrence of the biological reactions.
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関連論文
- Toxicological and pharmacological studies on coelomic fluid and body constituents of round-worms:(1). Symptoms of poisoning by these substances and their action on the mucous membrane of the eye
- Toxicological and pharmacological studies on coelomic fluid and body constituents of round-worms:(2). Their action against the circulatory system and some smooth muscle organs