Studies on the effect of drugs on the basic metabolism of rats
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概要
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The experiments have been carried out with a special apparatus of a simply closed type designed by author for the determination of basic metabolism of rats under the influence of drugs in recording the respiratory gaseous volume. Result : (1) Sulphonamides inhibit in general the basic metabolism. (2) Cardiac stimulants including n-hydroxy-camphor accelerate the gaseous metabolism; on the contrary, camphor inhibits. (3) The basic metabolism is decreased by phenobarbital and increased by the central stimulants. (4) The antihistaminics, N-dimethylaminoethyl phenotiazine HCl accelerates, while Benadryl inhibits. (5) With the sympathomimetics, benzylimidazoline HCl accelerates, and with TEAB there exists the inhibition, if any, but very weak.
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