臓器灌流薬物作用の温度係数
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概要
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The time needed to produce the selective effects at 10°, 20°, 25°, 30°, and 35°C was measured to find temperature coefficient on pharmacological action. The animals used for the experiment were the toad (Bufo vulgaris) and a kind of the freshwater fish (Ophicephalus argus <I>Cantor</I>), and were perfused their their hearts and the muscle of hind limb of the toad with drugs. Digitalis glycoside, <I>g</I>-strophanthin and acetylcholine were used as drugs for the heart perfusion, and acetylcholine, caffeine and guanidine for the muscle perfusion. All these drugs were in a wide range of their different concentrations. With those experiments the following conclusions were obtained : (1) The temperature coefficient of this empirical system indicates its minimum and nearly equal numerical value at the range of about 15°C to 30°C. However the temperature coefficient increases rapidly at the lower or higher than the range of the above temperatures, and all the changing points seemed to be at a certain temperature between 10°C and 15°C, or 30°C and 35°C. (2) According to the increase of the concentration of drugs, the temperature coefficient was apt to increase slowly. (3) Under the above mentioned facts, further, the following numerical values turn up when geometrically averaging a series of six results at each concentration and temperature. The above list indicates fairly resembling numerical value for each case. Each numerical value, however, was slightly different from others because of different animal species, Organs and drugs. (4) The temperature coefficient measured by the effect of drugs may be mainly due to a difference of temperature in adsorption rate of drugs, by which a satisfactory explanation will be given to that phenomena. It may therefore be said that drugs can produce a certain effect without any relation of temperature when a certain concentration of drugs is attained at the point of action. (5) The effect of acetylcholine on the heart and the muscle did not provide, the temperature coefficient. Assuming that acetylcholine in the tissues receives a rapid resolution, it may be understood that any difference of temperature can not be recognized in the time of action of acetylcholine, because acetylcholine rapidly reaches the tissues by the higher temperature and, at the same time, the destruction by cholinesterase proceeds quickly.
- 社団法人 日本薬理学会の論文