Pharmacological studies of synthetic vitamin K (Menadione)

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概要

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• The pharmacological effects of synthetic vitamin K<SUB>3</SUB> (2-methyl-1, 4-naphthoquinone) were studied and the following results were obtained : Initial dilation and subsequent constriction of blood vessels ; a slight rise of blood pressure; stimulation of respiratory movement; acceleration of intestinal and uterine muscle movement and marked diuresis. By a large amount of vitamin K3 there is observed inhibition of heart beat, and a fall of blood pressure. The minimal lethal dose by the subcutaneous injection is 6 mg per 10 g of body weight of mice.

• 社団法人 日本薬理学会の論文

著者

• 大鳥居 健

  新潟醫科大學藥理學教室

関連論文

• Pharmacological studies of synthetic vitamin K (Menadione)

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