Propylene glycolを溶媒とせる鼓膜表面麻酔薬の研究-(2)海〓外耳道に於ける表面麻酔効果の増強に就て-

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概要

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• This experiment was also carried out using the same method as described in the previous report [this Breviaria no. 15 (1951)].Results : (1) In the same concentrations the anesthetic action of nupercain and cocain bases on the mucous membrane of the external auditory canal of the guinea-pig were about twice stronger than their salts. (2) The anesthetic power of nupercain and propaesin was enhanced by the simultaneous application of a certain. dose of phenol, menthol, antipyrin, aminopyrin or saponin, and there existed also a synergic action between nupercain and propaesin. (3) The effect of nupercain was not increased by the addition of salicylic acid, methylene blue or glucose. (4) The effect of "thymkol", the mixed preparation containing the bases or hydrochloric acid salts of nupercain, propaesin, phenol, antipyrin, and saponin, each dissolved in PG, was found to be very powerful.

• 社団法人 日本薬理学会の論文

著者

• 山下 蕃

  長崎大學醫學部藥理學教室

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• Propylene glycolを溶媒とせる鼓膜表面麻酔薬の研究-(2)海〓外耳道に於ける表面麻酔効果の増強に就て-

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