モルモットTaenia coliにおけるアドレナリン作働性および非アドレナリン作働性抑制神経の衝撃伝達におけるProstaglandinの生理的役割
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概要
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Prostaglandin (PG) E<SUB>1</SUB>, PGE<SUB>2</SUB> and PGF<SUB>2α</SUB> and their biosynthesis inhibitor, indomethacin, were testedfor their effects on the inhibitory responses of taenia induced by electrical stimulation of adrenergic and/or non-adrenergic inhibitory nerves in the perivascular nerve-taenia preparation isolated from guinea-pig caecum. The response to adrenergic nerve stimulation was considerably reduced by PGE<SUB>1</SUB>and PGE<SUB>2</SUB>, while it was little affected by PGF<SUB>2α</SUB>. Although PGE<SUB>1</SUB> and PGE<SUB>2</SUB> produced contraction oftaenia, it may be possible to dismiss from consideration their action of contraction of taenia in accounting for their inhibitory effect on the response to nerve stimulation since the following observations were made, 1) when the taenia were contracted by histamine, the response to adrenergic nerve stimulation was not reduced and 2) in the presence of polyphloretin phosphate, PGE<SUB>1</SUB> and PGE<SUB>2</SUB> did not contract taenia but reduced the response to adrenergic nerve stimulation. In the presence of indomethacin, the response to adrenergic nerve stimulation was increased greatly. On the contrary, the inhibitory response to non-adrenergic inhibitory nerve stimulation was not affected by application of PGE<SUB>1</SUB>, PGE<SUB>2</SUB>, PGF<SUB>2α</SUB> and indomethacin. These results suggest that endogenous PG of E series in guinea-pig taenia may play a role in modulating adrenergic neurotransmission. Attempts to demonstrate that PG could operate on a non-adrenergic inhibitory neurotransmission by a negative feedback mechanism were without success.
- 社団法人 日本薬理学会の論文