新規なCa2+拮抗薬KB-2796の血液流動性に対する作用

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The hemorheological effect of KB-2796, 1- [bis (4-fluorophenyl) methyl] -4- (2, 3, 4-trimethoxybenzyl) piperazine dihydrochloride, was studied in guinea pigs and rabbits in comparison with those of flunarizine (FNZ) and pentoxifylline (PXF). KB- 2796 and FNZ at 10-100 μM dose-dependently prevented crenation of rabbit erythrocytes induced by the Ca<SUP>2+</SUP> ionophore A23187. After incubation of guinea pig whole blood at 37°C, blood micropore-filterability decreased and blood viscosity increased with the progress of erythrocyte crenation. After a 4-hr incubation, KB-2796 inhibited erythrocyte crenation and decreased blood filterability at a concentration of 30μM, and it increased blood viscosity at 10 μM. Treatment with FNZ (30 μM) and PXF (100 pM) also inhibited erythrocyte crenation and decreased blood filterability. Intravenous administration of KB-2796 at 3 mg/kg significantly inhibited the decrease of blood micropore-filterability after occlusion of the bilateral carotid arteries in rabbits. Although FNZ (3 mg/kg, i.v.) had no effect, PXF (3mg/kg, i.v.) produced significant inhibition. These results suggest that KB-2796 prevents increase of blood viscosity and decrease of blood filterability by inhibiting the crenation of erythrocytes and suggest that this effect may be useful for the improvement of hemorheology in ischemic disease.
社団法人日本薬理学会の論文