Recollection of the early years of the research on cytochrome P450

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概要

• 論文の詳細を見る

• Since the publication of the first paper on "cytochrome P450" in 1962, the biochemical research on this novel hemoprotein expanded rapidly in the 1960s and the 1970s as its principal roles in various important metabolic processes including steroid hormone biosynthesis in the steroidogenic organs and drug metabolism in the liver were elucidated. Establishment of the purification procedures of microsomal and mitochondrial P450s in the middle of the 1970s together with the introduction of molecular biological techniques accelerated the remarkable expansion of the research on P450 in the following years. This review paper summarizes the important developments in the research on P450 in the early years, for about two decades from the beginning, together with my personal recollections.<BR><BR>(Communicated by Masanori OTSUKA, M.J.A.)

• 日本学士院の論文

著者

• Omura Tsuneo

  Kyushu Univ. Fukuoka Jpn

• OMURA Tsuneo

  Kyushu University

関連論文

• Mitochondria-Targeting Sequence, a Multi-Role Sorting Sequence Recognized at All Steps of Protein Import into Mitochondria
• Structural diversity of cytochrome P450 enzyme system
• Recollection of the early years of the research on cytochrome P450

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