生体膜晶析工学の創成に関する基礎工学的研究

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概要

• 論文の詳細を見る

• Alzheimers disease (AD) is a progressive neurodegenerative disease characterized by extracellular amyloid plaques on the brain tissues, which involves amyloid fibrils formed by amyloid β protein (Aβ). Meanwhile, previous findings on fibril growth behavior of Aβ could not considerably give a plausible explanation on the induction of a variety of morphology of fibrils. There is a possibility that the biomembrane mediates a fibril growth behavior of Aβ. Besides, fibril growth has a similarity to a crystallization of protein molecule. Therefore, in this article, how (model) biomembrane could mediate a crystallization of Aβ(fibril growth) was investigated. First, it has been revealed, by using a model biomembrane (liposome), that the headgroup mobility associated with bound waters contributed to a dynamics of the lipid membrane. This dynamics was found to mediate the stability of protein conformation, especially a hydrogen bonding stability. Liposome could mediate the amyloid fibril formation behavior (nucleation, elongation, and morphology). Finally, an efficacy of biomembrane-mediated crystallization will be discussed.

• 日本膜学会の論文

著者

• 島内 寿徳

  大阪大学 大学院基礎工学研究科 化学工学領域

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