生体膜におけるNa+ポンプのメカニズム

概要

論文の詳細を見る
The sodium pump consists of two processes which are ATP hydrolysis and the ion-translocation across the cell membrane. There are still some questions regarding the mechanism of the coupling between the two processes, though the mechanism of Na+, K+-ATPase has been fairly well established. In 1972 Post et al. suggested that K+ ions or K+-congeners were occluded in Na+, K+-ATPase. Recently, direct evidences for the existence of occluded-ion forms of the enzyme were obtained from measurements of the off-rate of Rb+ ion or Na+ ion from the enzyme. As the occluded-ion forms appear to be intermediates in the process of the ion-translocation, studies on the ion-occlusions might be important to understand the coupling of the processes mentioned above. The K+-occlusion and Na+-occlusion were reviewed as well as some general properties of Na+, K+-ATPase.
日本膜学会の論文