麻酔薬と生体膜の相互作用
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More than a century after the discovery of anesthesia, the biological mechanisms of anesthetics is still not fully understood. Enthusiasm among anesthesiologists for elucidating the mode of action of anesthetics appears to have receded in recent years, presumably because the method of study became more oriented toward basic sciences. Recently, it is generally accepted that an interaction between anesthetics and biological membranes may play a pivotal role in anesthetic action on biological tissues and organs. The most likely mechanism of anesthetic action involves synaptic membrane, and anesthetic molecules may block neural transmission by uncertain mechanisms including membrane perturbation of neuronal system. In this article, the recent concepts regarding the interaction between anesthetics and biological membranes are reviewed.
- 日本膜学会の論文
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- 麻酔薬と生体膜の相互作用