糸球体基底膜をモデルとした荷電型限外濾過膜による血しょう蛋白分離

概要

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Polyacrylonitrile graft polymer with side chains of dimethylaminoethyl methacrylate was photochemically synthesized. The positively charged ultrafiltration membranes modeled after glomerular capillary wall were made by casting the graft polymer. Permeation of albumin and γ-globulin through the membranes was measured by using a buffered saline solution containing both proteins. The experiment yielded the following result that permeation of albumin was greater than that of γ-globulin in solutions at pH higher than the isoelectric point of albumin. Taking account of the molecular weight cut-off characteristic of the positively charged membranes, it was considered that the separation of the proteins was due to the interaction between the charge of the proteins and that of the membrane.
日本膜学会の論文