Temperature effect on drug release from poly (2-methacryloyloxyethyl phosphorylcholine-co-<I>n</I>-butylmethacrylate) membrane

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概要

• 論文の詳細を見る

• The release of drugs such as ketoprofen and indomethacin from polymer membrane of poly (2-methacryloyloxyethyl phosphorylcholine (MPC) -co-<I>n</I>-butyl methacrylate (BMA)) was investigated with attention to the unique characters of the copolymer as a hydrogel. The release rate of these drugs was increased with an increase in MPC content in the copolymer. The rate of hydration in poly (MPC-co-BMA) was increased with an increase not only in MPC composition and but also in temperature. Therefore, the release rate of drugs was reversibly regulated in response to the change in temperature. It can be concluded that the release of drugs from the MPC copolymer membrane was accelerated by the positive change of the hydration with an increase in temperature and was suppressed by the formation of skin layer at the surface of the membrane with a decrease in temperature.

• 日本膜学会の論文

著者

• NAKABAYASHI Nobuo

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• Nakabayashi Nobuo

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• Ueda Tomoko

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• Ishihara Kazuhiko

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 上田 智子

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 石原 一彦

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 中林 宣男

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

関連論文

• Biocompatibility of MPC : in vivo evaluation for clinical application
• In vitro and ex vivo blood compatibility study of 2-methacryloyloxyethyl phosphorylcholine (MPC) copolymer-coated hemodialysis hollow fibers
• Water-Soluble 2-Methacryloyloxyethyl Phosphorylcholine Copolymer as a Novel Synthetic Blocking Reagent in Immunoassay System
• Temperature effect on drug release from poly (2-methacryloyloxyethyl phosphorylcholine-co-n-butylmethacrylate) membrane
• Medical Application of Synthetic Membranes

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