Peptaibolとその誘導体のイオンチャネル特性

概要

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Peptaibols are a family of peptides which have a high fractional content of an α, α-dimethyl amino acid, α-aminoisobutyric acid (Aib), and which have an α-amino alcohol at the C-terminus. Peptaibol forms voltage gated ion channels in bilayer lipid membranes. Since, the movement of ions through membrane-spanning channel proteins is fundamental to a number of physiological processes, it is valuable to investigate the properties of peptaibol ion channels which resemble in the motif of pore structures with biological ion channels. Development of the techniques related to structure elucidation and synthesis of peptaibols allow us to examine the relationships between peptaibol structure and its channel properties more easily by using its synthetic derivatives. In this article focus is on the context of current development of structure elucidation, synthesis and studies of structure-activity relationships of peptaibols and their derivatives.
日本膜学会の論文
2003-03-01