BeelerおよびReuterのモデルによる心室筋活動電位のシミュレーション

概要

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Membrane action potentials of mammalian ventricular myocardial fibers were computed according to a mathematical model proposed by Beeler and Reuter.Eight simultaneous differential equations were solved by Runge-Kutta-Gills methods on a sudden displacement of the membrane potential from the resting level of-84 mV.At the threshold displacement to-60mV, the computed action potential was similar to the one by the above authors in action potential duration but differed from that in the pattern of action potential upstroke.Because of the graded response patterns of membrane action potential, these patterns were studied in detail by changing the displacement from-60 to-5O mV. The difference of the results of actual computation from those of an equation of convenient approximation was indicated. Antiarrhythmic agents of quinidine type are supposed to reduce the upstroke velocity of action potentials by affecting some parameters which govern the sodium inward current. The computation indicates that with a similar extent of a reduction of Vmax, drugs which reduce Na equilibrium potential would be expected to reduce overshoot and the membrane potential at the level of Vmax more markedly than drugs which reduce αj or gNa.