糖尿病と基底膜

概要

論文の詳細を見る
Alteration of basement membrane component in diabetes mellitus was reviewed. Recently, it has become evident that the basement membrane was composed of type 4 collagen, laminine and glycosaminoglycans. Presence of entactin and type 5 collagen was also claimed. Existence of fibronectin is controversial. Previously, studies on the basement membrane in diabetes were mainly concerned in the collagenous components. However, studies on the components other than collagen will be more important because they bear roles for the morphogenesis, metabolism and functions of basement membrane.<BR>Recently it was demonstrated that the glycosaminoglycans were reduced in diabetic basement membrane. Reduction of negative charge of basement membrane due to the loss of acidic residue of glycosaminoglycans was claimed to be the cause of the loss of charge selectivity observed in diabetic nephropathy. Fibronectin was reported to be increased in the renal glomeruli of the initial stage of diabetic glomerulosclerosis and to be decreased in the advanced nephropathy. Studies on laminin produced by EMS tumor implanted to the diabetic mice revealed no consistent changes. In diabetic glomerulosclerosis, laminin was reported to be decreased. Speculation on the mechanisms of the basement membrane thickening in diabetic microangiopathy was made on the bases of the reported evidences on the alteration of basement membrane components.