リファンピシンの免疫抑制作用

概要

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It is well known that Rifampicin (RFP) is one of the effective antituberculous drugs. Although reports on the immunosuppressive activity of RFP have been accumulating, it has not been thoroughly analysed whether immunosuppressive effects of RFP are mediated by thymus-derived T or bone marrow-derived B lymphocytes. In this paper, immunosuppressive effects of RFP on the functions of T and B lymphocytes were investigated in mice. Following responses were found to be suppressed by RFP 1) Humoral immune response to sheep red blood cells (SRBC) both in vivo and in vitro (Fig. 1, Fig. 2 and Fig. 3). 2) Induction of cell-mediated cytotoxicity to the allogeneic cells, which is one of the cell mediated immunity (Table). 3) Humoral immune response to a T-independent antigen, polyvinylpyrrolidone (PVP) (Fig. 4). 4) Mitogenic response and nonspecific anti-SRBC response elicited by lipopolysaccharide (LPS) from E. coli (Fig. 5, Fig. 6 and Fig. 7). 5) Mitogenic activity of concanavalin A (Con A) (Fig. 7).Data described above suggest that RFP has the suppressive effect on functions of both T and B lymphocytes. It remains to be resolved whether or not the immunosuppressive effectsof RFP as described are mediated through the suppressive effect of RFP on macrophages.
一般社団法人日本結核病学会の論文