気管支遮断術を施した肺の血管系の病理組織学的変化に関する実験的研究
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The bronchial occulusion is indicated for the far-advanced cavitary tuberculosis. In order to clarify the pathologic changes of the vascular system of the lung following the bronchial occulusion, the present experimental study was performed.<BR>An occulusion of the left main bronchus was performed in a series of 52 rabbits. After the operation the animals were killed at various periods of time, from 1 week to 18 months. In these materials angiography of the pulmonary vessels and the histological investigation were performed. In 3 rabbits the blood flow through the collapsed lung were estimated.<BR>The results obtained were as follows.<BR>1) Angiography with vermillio n and urografin conducted at one week after the operation, revealed the narrowing of the pulmonary arteries in the collapsed lung. The narrowing of the pulmonary arteries in the collapsed lung showed increase in its degree for the first three months, and it was more marked in the peripheral than in the proximal region of the collapsed lung, resulting in the poor visualization of the fine branches in the peripheral field of the lung. The poor visualization of the arterial trees gradually progressed from the peripheral to the proximal part of the collapsed lung.<BR>2) Histologically, intimal thic k ening of the pulmonary arteries was observed. The thickening seemed to begin from the arteries of the elastic type and advance to the peripheral branches of the muscular type.<BR>3) The pletysmography revealed that the blood flow through the collapsed lung was decreased to 2/8 of the blood flow of the non-colapsed lung at one hour after the bronchial ligation.<BR>4) It is thought that the diminution of the blood flow through the collapsed lun g is pathogenetically responsible for the intimal thicking and the elastosis of the pulmonary arteries in the collapsed lung.<BR>5) Narrowing of the capillary lumen of the alveolar septa was observed at one hour after the bronchial ligation, and it showed increase gradually. However, the gradual increase in the degree of the narrowing ceased approximately 2 weeks after the bronchial ligation.
- 一般社団法人 日本結核病学会の論文
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- 気管支遮断術を施した肺の血管系の病理組織学的変化に関する実験的研究