結核菌におけるStreptomycin耐性がkanamycin,Viomycin,Capreomycinの耐性上昇と交叉耐性とに及ぼす影響

概要

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Induction rate of resistance to kanamycin (KM), viomycin (VM) and capreomycin (CPM)and cross-resistance among these drugs were studied in tubercle bacilli. A streptomycin (SM)-sensitive strain of H37Rv and the SM-resistant strain isolated as one step mutant of the former were employed in the present study. Increasing degrees of resistance to KM, VM and CPM we r e induced by succesive culture of above strains in the 1% Ogawa's egg media containing an increasing amount of each drug. 1) Induction rate of resistance to KM, VM and CPM was much higher in the SM-resis tant strain than in the SM-sensitive strain. 2) In both SM-sensitive strain and SM-resistant strain, there were complete cross-resistance between VM and CPM, and partial cross-resistance between KM and VM, as well as between KM and CPM. 3) I n both SM-sensitive strain and SM-resistant strain, the increase of resistance to KM, VM and CPM was always associated with the increasing resistance to SM.
一般社団法人日本結核病学会の論文