肺結核と糖尿病--血中インスリン反応を中心として

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We conducted a study on the possible mutual relationship between pulmonary tuberculosis and diabetes. Out of 479 patients with pulmonary tuberculosis (male 351, female 128) who were admitted to Aisei Hospital between January, 1978 and December, 1981, 27 cases were associated with diabetes (5.6%). We investigates these 27 cases and obtained the following results:<BR>1) The onset of tuberculosis preceded the onset of diabetes in 13 patients (48.2%), the onset of diabetes preceded that of tuberculosis in 12 patients (44.4%) and the onset occurred almost simultaneously in 2 patients (7.4%).<BR>2) Parallel improvement for both diseases was observed in 9 out of 27 patients (33.3%), and following therapy, the blood sugar curves (GTT) in these patients approached normal patterns where as insulin in plasma (IRI) exhibited abnormally low levels with a small variation.<BR>We also measured the insulinogenic index (Δ/ΔBS). In the healthy group (n=50), the mean was 0.797±0.053; in the non-diabetic tuberculosis group (n=20), this mean was 0.444±0.055; and in the group with tuberculosis associated with diabetes (n=27), this mean was 0.204±0.042. Difference in the insulinogenic index among these 3 groups was statistically significant (t-test, p<0.001). Based on the above results, we concluded that pulmonary tuberculosis may be a factor that influences glucose metabolism.
一般社団法人日本結核病学会の論文