Relationship between Cancer and Tuberculosis:Effect of tubercle bacilli infection on transplanted tumors in the mouse

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The relationship between cancer and tuberculosisis still obscure inspite of many effortsabout this problem. In this report we performedseveral experiments as follows: 1) A: The living tubercle bacilli were directlyinjected into the subcutaneous solid tumorsof mice in order to know the direct effect oftubercle bacilli for Ehrlich's ascites tumor cells, but we could not find any special direct effect. B: First, the living tubercle bacilli wereintraperitoneally injected to Ehrlich's ascitestumor bearing mice. Then these tumor cellswere collected three days aftar tubercle dacilliinjection, and these collected cells were subcutaneouslyinoculated to the other mice. However, we could not find any difference in size oftumors between the tubercle bacilli pre-treatedgroup and the control group. Because of this, it does not seem that tubercle bacilli have anydirect effect for the Ehrlich's ascites tumorcells. 2) The living H37Rv were intravenously injectedbeforehand to the miceW and, two weeksafter, Ehrlich's ascites tumor cells were subcutaneouslyinoculated to these mice. Theinoculated tumor cells increased and made asubcutaneous solid tumor up to thirty daysafter inoculation, but after that the size of solidtumors in the H37Rv injected group graduallydecrease and finally became indetectable. Itseems to us that some anti-cancerous responseor ability will be produced in vivo due to preinoculationwith living tubercle bacilli to themice. However in the experiments using heatkilledH37Rv, H37Ra, BCG and ATM No.8 wecould not observe such a specific effect like theliving H37Rv experiment. This discrepancy aboutexperiment might be derived from the differencesof experimental methods and conditions. 3) The living H37Rv were intravenously injectedto the mice and, two weeks after, Ehrlich's ascites tumors cells were intraperitoneallyinoculated to these pre-treated mice. The survival time of the treated mice wasdefinitely prolonged as compared to the nontreatedcontrol animals. In this case, we hadto use about 1/100 tumor cells of solid tumorexperiment in order to know the definite prolongationof survival time. Therefore, it is theobvious matter that the living tubercle bacilli H37Rv have some indirect anti-cancerous effecton transplanted solid and ascites tumors in themice. 4) No relationship was observed betweennumbers of tubercle bacilli colonies in the miceorgans by culture and, the sizes or weights ofsolid tumors and spleens. 5) It is still obscure that the indirect anticancerouseffect of tubercle bacilli will be dueto the enhanced activity of reticulo-endothelialsystem or the enhanced capacity for antibodyproduction. Experiments about this are now in progress.
一般社団法人日本結核病学会の論文

Relationship between Cancer and Tuberculosis:Effect of tubercle bacilli infection on transplanted tumors in the mouse

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