Kirchner半流動培地における結核菌のRifampicinに対する臨床耐性の境界値と耐性獲得形式について

概要

論文の詳細を見る
Far advanced severe pulmonary tuberculosis patients were treated by the intermittent administration of rifampicin, and their sputa findings were observed.The critical concentration. of clinical rifampicin resistance and the acquirment pattern of rifampicin resistance were studied in 47 cases; and the resistance test was done by using Kirchner's semi-liquid agar media with. 10% albumin. Following results were obtainned. 1) Tubercle bacilli became resistant to rifampicin in a short period. If the concentration of clinical rifampicin resistance for tubercle bacilli on Kirchner's semi-liquid agar media was defined as 1mcg/ml complete resistance, the rate of cases acquired resistance to rifampicin by the intermittent administration was 11.6% at 1 month, 25.0% at 2 months, 37.2% at 3 months, 30.8% at 4 months, 42.4% at 5 months and 48.6%, at 6 months. 2) It would be safe to say that the critical concentration of clinical rifampicin resistance for tubercle bacilli is 1mcg/ml complete resistance. 3) The acquirment pattern of rifampicin, resistance of tubercle bacilli in rifampicin treated patients was mainly the multi step-pattern and in a few cases single step-pattern on Kirchner's semi-liquid agar media.
一般社団法人日本結核病学会の論文