SOME BIOCHEMICAL STUDIES ON CERTAIN TRYPTOPHAN METABOLITES IN TUBERCULOUS GUINEA PIGS

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概要

• 論文の詳細を見る

• Tryptophan and some indole derivatives proved to be tuberculostatic both in vitro and in vivo. Indole, in therapeutic doses was effectively tuberculostatic in guinea pigs and human beings. Indole acetic and indole-propronic acid were less effective as tuberculostatic agents. Skatol had also a tuberculostatic effect both in vitro and in vivo, but in large therapeutic doses it was toxic to mice which limited the experiment.<BR>Some indole compounds have been found to increase in blood and urine of tuberculous patients and to diminish as a metabolic consequence to treatment with traditional antituberculous drugs This work was therefore conducted to study the metabolism of some indole compounds in tuberculosis, namely serum total indoles and blood serotonin level, in tuberculous guinea pigs.

• 一般社団法人 日本結核病学会の論文

著者

• SOLIMAN K.M

  From the Biochemistry Department, Faculty of Medicine, Cairo University

• SALLAM N.

  From the Biochemistry Department, Faculty of Medicine, Cairo University

• Abdel Kader

  From the Biochemistry Department, Faculty of Medicine, Cairo University

• ABDELAZIZ M.T

  From the Biochemistry Department, Faculty of Medicine, Cairo University

• TAWDROUS G.A.

  From the Biochemistry Department, Faculty of Medicine, Cairo University

関連論文

• SOME BIOCHEMICAL STUDIES ON CERTAIN TRYPTOPHAN METABOLITES IN TUBERCULOUS GUINEA PIGS

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