RELATIONSHIP BETWEEN CANCER AND TUBERCULOSIS:A Retarding Effect of BCG Inoculation for Tumor Induction in Mice with INH or Urethane-4 NQO Injections

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In our previous report, retarding effects for tumor growth, of living tubercle bacilli wereobserved with inoculated tumors in mice. The present experiment deals with the relationshipbetween BCG inoculation and tumor induction in mice with INH or urethane-4 NQO injections.<BR>A dd 0 female mouse was intraperitonealy injected with 2mg/0.2ml of INH saline solutionperiodically for 15 weeks (total dosis 60mg). Nine months after, pulmonary adenoma wasinduced in 15 out of 24 mice (62.5%). This tumor induction was markedly depressed by intravenous injection with dried living BCG (four injections with 0.5mg BCG vaccine per mouse intotal). Tumor induction rate was 11.7% in this group.<BR>In another experiment, dd 0 female mice were subcutaneously injected with each 10mgurethane once a week for 11 weeks, and afterwards were given, for further 10 weeks, foursubcutaneous injections with each 0.5mg of 4 NQO. Thirty weeks after, tumor induction wasobserved in 17 out of 20 mice (85.0%). One intravenous injection with 0.2mg BCG vaccinehad not any inhibiting effect for tumor induction. No tumor induction was observed in nontreated control and in BCG inoculated mice.<BR>There was no pathological difference between induced tumors With INH and urethane-4NQO injections. All induced tumors were pulmonary adenoma and no malignant change wasobserved.<BR>The authors were very much interested in the fact that cholesterine pneumonia was foundin many cases of INH-adenoma, the reason of which is not clear at present.
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RELATIONSHIP BETWEEN CANCER AND TUBERCULOSIS:A Retarding Effect of BCG Inoculation for Tumor Induction in Mice with INH or Urethane-4 NQO Injections

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