On the Relation of Immunity to the Disfunctioning of t he Reticulo-endotherial Cellular System.

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It is a well known fact that reticulo-endo t h erial cellular system is the seat of antibody production. In order to determine the. fate of immune bodies in relation to disturbance of the function of reticulo-endotherial system we made the following experiments. After immunising rabbits with tubercle bacillus, typhoid B. or staphylococcus the animals were injected with India ink to block reticulo-endotherial system. Then the fate of antibodies was followed by peagocytic and agglutinin tests. The follow-1results were obtained: 1. Phagocytosis o f rabbit, which is immunised with bovine type of tubercle B. was very much reduced after blocking with India ink. Autopsies showed more marked pathologicd changes in the blocked animals than in the control animals.2. Phagocytosis of rabbits, which had been immunised with typhoid B. or staphylococcus was also reduced in the blocked animals than in the control animals. Agglutution, however, showed no difference. Thus it may be said tha t blocking of reticulu-endotherial system with India ink reduces phagocytic action of immunised animals, but such procedure does not disturb agglutination action.
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