ビタミンKの結核菌に及ぼす影響
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概要
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Studying on the influence of Vitamin K<SUB>3</SUB> (2-Methyl-1.4-naphthoquinone) on tubercle bacilli in vitro and in vivo, the authors obtained the following results.<BR>1) In Kirchiner's fluid media, Mycobacterium tuberculosis typus humanus and typus gallinaceus are not only strictly prohibited their growth, but also killed thoroughly by Vitamin K<SUB>3</SUB> in the dilution of 2X10<SUP>-4</SUP> and the former is also checked fairly in the dilution of 10<SUP>-5</SUP> but Myc. the. typus bovinus is killed iu 10<SUP>-4</SUP> and strongly suppressed in 2 x 10<SUP>-4</SUP>.<BR>2) On glycerine agar slants, containing Vitamin K3 in the dilution of 2X10<SUP>-7</SUP>, typus humanus and typus gallinaceus are both remarkably accerated their growth.<BR>3) The inhibitory and promoting influences, above mentioned, on tubercle bacilli by Vitamin K<SUB>3</SUB> are not able to be obviously observed on egg media such as Oka-Katakura's.<BR>4) Subcutaneous injections of Vitamin K, daily 1.5-2.5mg during about 4 months, reveal some therapeutical effects against the experimental tuberculosis of guinea pigs.
- 一般社団法人 日本結核病学会の論文