The Local Effect of Cortisone on Tuberculin Reaction. Report 2.

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The local effect of cortisone on tuberculin reaction of healthy men was observed by the same method used in the previous report. Old tuber culin in dilution of 1: 2, 000 was injected intracu- taneously into the flexor surface of one forearm. On the other side, various concentration of saline suspended crystaline cortisone (1. 25 mg cortisone acetate) mixed in old tuberculin was injected intra- cutaneously as shown in the table. The reactions were read at 16, 24, 40, 48, 64 hours and 7 days after injection. Erythema was measured in diametelesss anin durationon was measured in the pinch-up thickness of the injected site.<BR>The following results were obtained:<BR>The tuberculin reactions were diminished by cortison in most of the cases, even by adding 0.05 cc of 1: 20 cortisone (0.0625 mg) to old tuberculin. The in duration was effected more strongly than the redness. And the reactions at 48 hours were effected more clearly than those at 24 hours. (The results of the study was reported at the 18th Annual Meeting of Japanese Society for Public Health in 1962).