F群溶血レンサ球菌のRタンパク抗原の存在特にO′Mahoney(Colindale)菌株からの証明

概要

論文の詳細を見る
By the aid of Ouchterlony's agar diffusion and immunoelectrophoretic techniques, it was found that cells of Group F streptococcal reference strain "O'Mahoney (Colindale)" contained at least three protein antigens having specificities different serologically from one another.The three protein antigens should be considered as R-protein antigens on the basis of the following characteristics.(1) They were resistant to trypsin-digestion, by which streptococcal M-protein antigen will be affected. (2) They were also resistant to heating at 100C for 15min at pH 2.0, by which streptococcal T-protein antigen will be affected. (3) They were inactivated by pepsin-digestion, by which T-protein antigen will not be affected.It should be considered that one of the three protein antigens corresponds partially to 28R-protein antigen which was initially reported by Lancefield in 1943, since the precipitation line between that protein antigen and anti-28R-protein serum showed a remarkable spur formation on agar gel plate. From the results of Ouchterlony's agar diffusion test, it is inferred that the other two protein antigens contained in the definite strain may be specific antigens entirely different from any of the protein antigens, i.e., 28R, M, T and Group B Ibc.
日本細菌学会の論文