マウス腹腔内におけるBacillus cereus及びBacillus subtilis芽胞の発芽,outgrowth,と栄養細胞の増殖について

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To explore the toxicity of Bacillus cereus, the fate of spores injected into the mouse peritoneal cavity was compared between this organism and Bacillus subtilis.One hour after injection of about 1.8×109 spores of B. cereus, most of the spores were found to have been phagocytized by phagocytic cells and a few as germinated ones in the peritoneal cavity. Two hours after injection, the germinated spores began to outgrow. Outgrown vegetative cells started to proliferate. Three hours after injection, they showed a marked proliferation, while some of them and some germinated spores were engulfed by phagocytic cells. By that time the peritoneal cavity was filled with proliferating vegetative cells. All the mice died during a period from 4 to 6 hours after injection.The MLD of B. cereus spores for mice by the intraperitoneal route was calculated as 4.35×108.In contrast, when about 1.6×109 spores of B. subtilis were injected intraperitoneally to mice, some of them germinated in the peritoneal cavity, and only a few of them were able to outgrow. Outgrown vegetative cells hardly proliferated. Thus no death occurred to the mice injected with B. subtilis spores.
日本細菌学会の論文