実験的コレラ感染と防御因子-1-

概要

論文の詳細を見る
1. Seventy-two of 82 infant rabbits born from 12 rabbits immunized with killed Vibrio cholerae (NIH 41 Ogawa) were inoculated with live <I>V. cholerae</I> by Dutta's method (Dutta test). Fifty of them survived and were subjected to the aggulutination test. As a result, 31 rabbits were proved to be carriers, and three of them discharged the bacteria for 2 weeks. Two to 3 months after the Dutta test the intestinal loop test (De test) was performed on the rabbits of both carrier and noncarrier groups. The carrier group developed “crisis” less frequently than the non-carrier group. The serum antibody titer remained at a low level over an interval of time between Dutta and De tests, irrespective of the carrier state.<BR>2. Ten of the 82 infant rabbits underwent the De test without the preceding Dutta test when they were 2 to 3 months old. The contents of intestinal loops of rabbits positive for the De test were all positive for this test on other rabbits. No vascular permeability factor was detected from them.<BR>3. Histopathologically, rabbits strongly positive for the De test using t he live bacteria exhibited necrotic, desquamative, and suppurative changes in the intestine. In contrast, no suppurative changes were observed in the intestine of rabbits strongly positive for the De test using cell-free cholera enterotoxin. The intestinal tract of these rabbits was remarkably distended, with its wall extremely flattened.
日本細菌学会の論文