海堡に棲息するドブネズミ(Rattus norvegicus)から分離されたブドウ球菌の生物学的性状,薬剤感受性ファージ型およびマウスに対する病原性について

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In order to clarify the correlations between staphylococci of rat and human origin, experiments were made on cultures of isolates from Norway rats, Rattus norvegicus, which had been captured on a small solitary island in Tokyo Bay over a period from March to April, 1969. One hundred and twelve cultures of hemolytic positive staphylococci were isolated from the skin and rectum in 71 out of the 84 rats tested, and examined for biological properties, drug sensitivity, phage type, and pathogenicity for mice.The results obtained are as follows.1. All the hemolytic positive strains produced coagulase, DNase, phosphatase, fibrinolysin and lysozyme, and reduced nitrate to nitrite. They were positive for egg-yolk tests. Almost all, or 98% of them produced gelatinase and lipase, and acidified milk with clotting.2. In hemolysis tests, 55%, 36%, 5% and 4% of them showed α-, δ-, αβ-, and β-hemolysis, respectively.3. Especially in biological characteristics, 31% of the cultures were mannitol-non-fermenters in aerobic condition, but were proved to be fermenters in anaerobic condition.4. In drug sensitivity tests, 32% and 5% of the cultures were relatively resistant to penicillin and streptomycin, respectively. The minimal growth inhibiting dose (MID) was higher than 12.5mcg/ml in these cultures. On the other hand, 30% of the cultures were resistant to sulfathiazol and showed a MID higher than 100mcg/ml. All the cultures were sensitive to chloramphenicol, oleandomycin and erythromycin, showing a MID less than 3.1mcg/ml.5. Phage typing was carried out using the basic set recommended by the International Committee for Staphylococci. As a result, 28% of the cultures were typable, and 84% of them found to belong to group III with the same lytic pattern.6. The representative cultures of mannitol-non-fermenters in aerobic condition were lower in virulence than those of mannitol-fermenters in mouse lethality tests. There was, however, one remarkable difference between them in ability to induce abscess in mice by subcutaneous injection.
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海堡に棲息するドブネズミ(Rattus norvegicus)から分離されたブドウ球菌の生物学的性状,薬剤感受性ファージ型およびマウスに対する病原性について

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