ファブリシウス嚢依存免疫系の個体発生に関する検討
スポンサーリンク
概要
- 論文の詳細を見る
A study was made on the ontogenetic development of humoral immunity derived from the bursa of Fabricius in chickens. The dynamics of hemolytic plaque-forming cells (PFC) were investigated following intravenous injection with sheep erythrocytes. Experiments were carried out on the effects of transfer of the bursal and splenic cells in "bursaless" birds. The following findings were obtained.1) Immunocompetent X-cells, i.e. the progenitors of PFC-producing hemolytic antibody, appeared in peripheral lymphoid tissue 5 days after hatching, and continued to show a rapid increase until about 2 weeks of age. Thereafter, the relative number of X-cells among the lymphoid cells was at a constant level during the remaining period of development. However, the absolute number of X-cells continued to increase with growth of the lymphoid organs. Be the matter as it may, it has been verified that the immunological maturation can be expressed as an increase in bursa-dependent X-cells.2) Acomplete loss or suppression of the humoral antibody-producing capacity of "bursaless" chickens was not due to a disorder of antigen-processing activity of macrophages responsible for antigenic information, but due to the absence or decrease of X-cells in peripheral lymphoid tissue.3) Although the bursal lymphoid cells acquired immunocompetence in situ by a still unknown mechanism, they were not directly involved in the immune response of antibody production. It was confirmed that they had migrated into the peripheral lymphoid tissue in neonatal life and then functioned as X-cells, which proliferated and differentiated in response to antigenic stimuli and turned to antibody-producing cells.
- 日本細菌学会の論文