Wassermann reaginの免疫電気泳動像,ならびにRPCF,FTA抗体との発現時期の比較について

概要

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By using the immune electrophoresis method, analysis was made on Wassermann's reagin refined from the sera of syphilitic patients at different stages. Investigation was also made on changes in the time process of antibody distribution. The results obtained are summarized as follows.1) In Ig-G, Wassermann's reagin had an activity in all stages of syphilis. In Ig-M, however, an activity on syphilis was observed only in the early stage. From then on and after the third stage, all sera were inactive. It should be noted that activity was recognized also in Ig-A from the early stage, and that it was absent only in the fourth stage of syphilis.2) By inoculating the Nichols strain of Treponema pallidum into the testicular parenchyma, syphilis was established experimentally in adult rabbits. Then the VDRL test, Wassermann Ogata method, and RPCF and FTA tests were performed on these rabbits. All the tests were compared with regard to the appearance-time of reaction. As a result, the FTA test brought about positive results four days after the inoculation. The RPCF test gave rise to a positive reaction six to eight days after the inoculation. The positive reaction to the VDRL test and Ogata method occurred eight to ten days after the inoculation.3) The FTA titer was resorbed by VDRL-antigen, but it did not decrease. In conclusion, FTA and RPCF antibodies were considered to be entirely different from each other.
日本細菌学会の論文