ブドウ球菌のα-毒素産生に及ぼすアミノ酸とペプチドの影響について
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概要
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Using synthetic medium containing 7 amino acids, the influences of component amino acids and 8 synthetic peptides on the growth and α-toxin production of Staphylococcus aureus were investigated.Test organisms were strain Terajima and 42 strains isolated from clinical specimens.Among amino acids in the basic medium, tryptophan was harmful for both growth and α-toxin production.The growth of strain Terajima was enhanced by the addition of β-alanyl-L-histidine, DL-alanyl-L-leucine or glycyl-L-asparagine respectively to the basic media containing 6, 5 or 4 amino acids, and the α-toxin production was accelerated by the addition of β-alanyl-L-histidine, glycyl-L-asparagine or glycyl-glycine to the same compositions. Also in the other 8 strains, the addition of β-alanyl-L-histidine, glycyl-L-asparagine and glycyl-glycine to the same compositions caused the acceleration of their α-toxin production.It was likely that these promoting activities of growth and α-toxin production by peptides were due to the action of splitted component amino acids, because such promotion of peptides was completely replaced with the addition of component amino acids at equimolar concentration.As for the other ingredients of the basic composition, sucrose was superior to glucose both for the growth and α-toxin production. In the early stage of incubation, the addition of nitrogen gas in the atmospheric air seemed more effective than carbon dioxide.
- 日本細菌学会の論文